Spatial Transcriptomics
Our end-to-end service is supported by Vizgen MERSCOPE platform, enabling us to provide high-resolution, spatially resolved gene expression data that is crucial for both basic research and clinical applications.
Firalis Molecular Precision positions itself as a leading certified Vizgen service-provider in Europe.
What is Spatial Transcriptomics ?
Spatial transcriptomics is an approach allowing to obtain gene expression data in its spatial context.
In fact, it allows for the simultaneous detection of thousands of genes within a tissue sample, while preserving its native spatial organization.
This approach has broad applicability in the fields of biology, medicine, and drug discovery.
Our service uses Vizgen's patented MERFISH technology, which enables the detection of up to 500 genes/panel in a single tissue sample.
The MERFISH technology provides high spatial resolution, allowing for the vizualisation of gene expression patterns at the single-cell level.
Our genomics experts leverage this cutting-edge technology to offer an end-to-end service, ranging from sample preparation and data generation to analysis and visualization.
We also provide customized data analysis solutions to aid resarchers in gaining insights from their generated data.
MERFISH technology principle
MERFISH is an image-based transcriptomic technology measuring both expression and spatial information of RNA in individual cells from tissue slices. It allows massive multiplexing single molecule FISH measurement.
Individual RNA species are encoded by error robust barcodes using combinatorial oligonucleotide labeling. Sequential rounds of oligonucleotides hybridization and imaging by a high resolution fluorescence microscope measure barcodes for spatially resolved RNA quantification of up to 500 genes.
Conducting a MERFISH experiment
Fixation
Tissue samples are fixed to preserve their structure.
Hybridization
Samples are hybridized with specially designed DNA probes.
Imaging
Use a fluorescence microscope to capture images of the samples.
Detection
Identifying and localizing each RNA molecule based on its fluorescent signal combination.
Having the MERSCOPE Platform in our labs and leveraging Vizgen’s various panels tailored for different research needs, allows us to map gene expression within your tissue samples with exceptional spatial detail, offering deep insights into tissue architecture and molecular processes.
This supports a range of applications, including biomarker discovery, understanding disease mechanisms, and analyzing cellular heterogeneity.
By providing comprehensive spatiotemporal gene expression data, we help you advance your research in drug development, disease modeling, and personalized medicine.
Why Firalis Molecular Precision Is the Best Partner for Your Project
Qualified team
Our experts have extensive experience in sequencing and bioinformatics analysis and are committed to providing personalized assistance throughout your entire project for a successful project outcome.
High-quality data
Our genomics experts leverage cutting-edge technology and quality control measures to ensure high-quality data generation and work closely with you to ensure that your research objectives are met.
Certified service provider
We are positioned as a leading certified service-provider in Europe for Vizgen’s MERSCOPE Platform. We adhere to the highest standards of quality and performance, ensuring that our clients receive accurate, reliable, and actionable data.
OUR COMMITMENT
Timeliness
We are committed to timely delivery and efficient project execution, ensuring that your research progresses according to schedule
Tailored Solutions
We are dedicated to understanding your goals and providing customized services with proactive communication throughout the project.
Quality Assurance
We follow strict, accredited procedures to guarantee the accuracy and reliability of your data.
Innovation
Our specialists leverage advanced technologies and methodologies to deliver innovative solutions tailored to your project.
